After Nearly a Decade-Long Decrease, Testosterone Prescribing Rates Rising Again

Testosterone replacement therapy is prescribed to treat low testosterone (low T) levels, also known as hypogonadism.¹ Prescribing rose sharply in the United States through the 2000s and early 2010s, a period marked by direct-to-consumer low T awareness campaigns and wider availability of convenient topical formulations.² As use expanded, questions emerged about cardiovascular safety. In March 2015, the U.S. Food and Drug Administration (FDA) required labeling changes cautioning that testosterone products are not approved for age-related low testosterone and warning of a possible increased risk of heart attack and stroke.³ Prescribing subsequently declined.⁴ However, in February 2025, the FDA removed the boxed cardiovascular warning from all testosterone products after the 2023 TRAVERSE trial found testosterone therapy was not associated with an increased risk for major adverse cardiac events among men with hypogonadism and elevated cardiovascular risk.^5,6 Telehealth and direct-to-consumer men’s health services have grown in recent years as well. It is unclear how testosterone prescribing practices have evolved with these changes.

We studied 109 million men aged 18 and older who had at least one healthcare encounter between January 2012 and June 2026 and examined the percentage that had an active testosterone prescription. Rates gradually declined from a peak of 0.83% in 2013 to a low of 0.64% in 2021, as seen in Figure 1. Beginning around 2022, prevalence rose, reaching 0.93% in 2025 and 0.95% by mid-2026.

The resurgence was evident across nearly every age group, though its magnitude varied. Men aged 50–64 maintained the highest prevalence throughout, reaching 1.57% in 2025, up from a prior peak of 1.30% in 2013. Men aged 30–39 (0.57% in 2025), 40–49 (1.35%), 65–74 (1.06%), and 75 and older (0.57%) each exceeded their own early-2010s peaks as well. Men aged 18–29 had the lowest rates with smaller overall changes following the same patterns as the older age groups, with rates between 0.10% and 0.15% throughout the study period.

These data come from Cosmos, a dataset created in collaboration with a community of Epic health systems representing more than 310 million patient records from 2,000 hospitals and more than 49,000 clinics from all 50 U.S. states, Canada, Lebanon, and Saudi Arabia. Graphics by Brian Olson.

1. Cleveland Clinic. Low Testosterone (Low T): Hypogonadism, Symptoms & Treatment. Cleveland Clinic. Reviewed February 23, 2026. Accessed July 27, 2026. https://my.clevelandclinic.org/health/diseases/15603-low-testosterone-male-hypogonadism
2. Baillargeon J, Urban RJ, Ottenbacher KJ, Pierson KS, Goodwin JS. Trends in androgen prescribing in the United States, 2001 to 2011. JAMA Intern Med. 2013;173(15):1465-1466. doi:10.1001/jamainternmed.2013.6895
3. FDA Drug Safety Communication: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use. U.S. Food and Drug Administration. Published March 3, 2015. https://wayback.archive-it.org/7993/20161022203711/http://www.fda.gov/Drugs/DrugSafety/ucm436259.htm. Accessed July 23, 2026.
4. Baillargeon J, Kuo YF, Westra JR, Urban RJ, Goodwin JS. Testosterone prescribing in the United States, 2002-2016. JAMA. 2018;320(2):200-202. doi:10.1001/jama.2018.7999
5. Lincoff AM, Bhasin S, Flevaris P, et al. Cardiovascular safety of testosterone-replacement therapy. N Engl J Med. 2023;389(2):107-117. doi:10.1056/NEJMoa2215025
6. FDA issues class-wide labeling changes for testosterone products. U.S. Food and Drug Administration. Published February 28, 2025. https://www.fda.gov/drugs/drug-alerts-and-statements/fda-issues-class-wide-labeling-changes-testosterone-products. Accessed July 23, 2026.