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Cosmos Study

Knee Replacement Failure More Likely in Patients with a Higher BMI

December 7, 2023
Dual-Team Study
Team A:Blaine Franklin, PT, DPTAlex Piff
Team B:Kersten Bartelt, RNBrendan Joyce

Key Findings

  • Patients with a higher BMI have a greater risk of knee replacement failure within a year of the procedure. 
  • Patients with a BMI over 50 are more than twice as likely to have a failure compared to patients with a BMI between 18.5 and 35. 

Total knee replacement (TKR) is a procedure performed primarily for arthritis with the goal of relieving pain and improving quality of life.1 Some studies have found that patients with a body mass index (BMI) greater than 30 have an increased risk of infection and repeat knee replacement.2 We sought to understand how a patient’s starting BMI affects outcomes after a TKR. 

We studied 344,269 patients who had a total knee replacement between January 1, 2017, and July 31, 2023, to determine whether there were differences in rates of failure after a TKR based on the patient’s starting BMI. We considered mechanical failures, infections, embolism, and hemorrhage as failures. Patients with class 3 obesity (BMI over 40) had the highest rate of failure within the first year after their TKR, as seen in Figure 1. Patients with a BMI over 50 were more than twice as likely to have a replacement failure compared to those with a BMI between 18.5 and 35. While the rate of failure was high in the underweight group (BMI under 18.5), it was not statistically significant. 

Figure 1
Knee Replacement Failure Rates by BMI
Knee Replacement Failure Rates by BMI
Figure 1. Knee replacement failure rates by patient’s starting BMI.

We also evaluated whether a patient’s starting BMI affected recovery time after a TKR surgery. We found that the average number of physical therapy appointments per week does not vary greatly across BMI classes, at around 2.25 sessions per week. The average length of time a patient goes to physical therapy after a TKR also did not vary much between BMI classes, with all classes going for 36.8 to 44.5 days. 


These data come from Cosmos, a HIPAA-defined Limited Data Set of more than 220 million patients from 222 Epic organizations including 1,272 hospitals and more than 27,200 clinics, serving patients in all 50 states and Lebanon. This study was completed by two teams that worked independently, each composed of a clinician and research scientists. The two teams came to similar conclusions. Graphics by Brian Olson. 

References

  1. Martin, G. M., & Harris, I. (2023, September 12). Total knee arthroplasty. UpToDate. https://www.uptodate.com/contents/total-knee-arthroplasty?search=total%20knee%20replacement&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1 
  2. Kerkhoffs, G. M. M. J., Servien, E., Dunn, W., Dahm, D., Bramer, J. A. M., & Haverkamp, D. (2012). The influence of obesity on the complication rate and outcome of total knee arthroplasty: A meta-analysis and systematic literature review. The Journal of Bone and Joint Surgery. American Volume, 94(20), 1839–1844. https://doi.org/10.2106/jbjs.k.00820