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Cosmos Study

Maternal ADHD Correlated with Increased Risk of Postpartum Depression

June 21, 2023
Dual-Team Study
Team A:Kersten Bartelt, RNAlex Piff 
Team B:Gretchen Vitek, RN, MSNEric Barkley

Key Findings

  • Mothers with ADHD are 24% more likely to be diagnosed with postpartum depression than mothers without ADHD. 

We recently noted that attention deficit hyperactivity disorder (ADHD) diagnoses are increasing, especially in women of child-bearing age.1 Additionally, the CDC noted that self-reported postpartum depression symptoms are also increasing.2 A study of pregnant women in Sweden showed that women with ADHD are much more likely to be diagnosed with both postpartum depression (PPD) and postpartum anxiety, but the greatest risk was in those who had a history of depression and anxiety diagnoses.3  

We wanted to understand whether pre-pregnancy ADHD without a history of depression was correlated with a mother’s risk of developing PPD. We studied 15,488 pregnancies for mothers with ADHD and 61,952 pregnancies for mothers without ADHD to assess the relative risk of PPD in both populations. We matched the two populations based on race and ethnicity of the mother, social vulnerability index, maternal age at delivery, singleton or multiple birth, pre-pregnancy anxiety diagnosis, and self-reported measures of substance use, food scarcity, intimate partner violence, and stress.  

We found that mothers with ADHD who have no history of depression are 24% more likely to be diagnosed with PPD than mothers without ADHD who have no history of depression, as shown in Figure 1. 

Figure 1
Postpartum Depression Rate in Mothers with and Without ADHD
Postpartum Depression Rate in Mothers with and Without ADHD
Figure 1. Rates of PPD in mothers with and without ADHD.

These data come from Cosmos, a HIPAA-defined Limited Data Set of more than 190 million patients from 208 Epic organizations including 1,197 hospitals and more than 25,400 clinics, serving patients in all 50 states and Lebanon. This study was completed by two teams that worked independently, each composed of a clinician and research scientists. The two teams came to similar conclusions. 

References

  1. Russell J, Franklin B, Piff A, et. Al. Number of ADHD Patients Rising, Especially Among Women. Epic Research. Mar 30, 2023. https://www.epicresearch.org/articles/number-of-adhd-patients-rising-especially-among-women. Accessed on May 11, 2023. 
  2. Bauman BL, Ko JY, Cox S, et al. Vital Signs: Postpartum Depressive Symptoms and Provider Discussions About Perinatal Depression — United States, 2018. MMWR Morb Mortal Wkly Rep 2020;69:575–581. DOI: http://dx.doi.org/10.15585/mmwr.mm6919a2 
  3. Andersson A, Garcia-Argibay M, Viktorin A, et al. Depression and anxiety disorders during the postpartum period in women diagnosed with attention deficit hyperactivity disorder. J Affect Disord. 2023;325:817-823. doi:10.1016/j.jad.2023.01.069