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Cosmos Study

More Than Half of Kids Who Tested Positive for Lead Exposure at Two Years of Age Tested Negative One Year Prior

November 14, 2024
Dual-Team Study
Team A:Kersten Bartelt, RNJoe Deckert, PhD
Team B:Blaine Franklin, PT, DPTTim Keogh

Key Findings

  • More than half of the children who tested positive for lead exposure at 24 months old were negative for lead exposure at 12 months old. 
  • Most children who tested positive for lead exposure at 12 months old went on to have a negative test at 24 months old. 

Medicaid recommends children have their blood lead levels tested at 12 and 24 months old.1 Those not on Medicaid are advised to get tested if they are considered high-risk, which includes factors such as housing built prior to 1978, known exposure to lead, and low income, though some health departments are encouraging this practice for all children.1,2 

To assess the potential benefit of a second lead level test, we studied 42,709 children who had their blood lead levels tested at both 12 and 24 months of age. We found that only 0.53% of children tested positive at both 12 and 24 months of age. We found that an additional 1.72% had a positive blood lead level at 24 months after having tested negative at 12 months. This indicates that further testing among those whose initial test was negative is beneficial in identifying future exposure to lead. Conversely, 1.47% of children tested positive at 12 months then went on to test negative at 24 months, indicating improvement one year later. Of note, overall positivity rates remain low, as seen in Figure 1.

Figure 1
Lead Testing Positivity Status at 12 and 24 Months of Age
Lead Testing Positivity Status at 12 and 24 Months of Age
Figure 1. Lead test results among patients tested at 12 and 24 months of age. A positive lead level is a test result greater than 5 µg/dL. 

Original Publication Date: November 14, 2024
Last Updated: December 11, 2024

These data come from Cosmos, a dataset created in collaboration with a community of Epic health systems representing more than 277 million patient records from 1,500 hospitals and more than 36,000 clinics from all 50 states, Lebanon, and Saudi Arabia. This study was completed by two teams that worked independently, each composed of a clinician and research scientists. The two teams came to similar conclusions. Graphics by Brian Olson. 

References

  1. Testing for lead poisoning in children. Childhood Lead Poisoning Prevention. U.S. Centers for Disease Control and Prevention. Published May 23, 2024. https://www.cdc.gov/lead-prevention/testing/index.html. Accessed July 25, 2024. 
  2. DHS asking parents to test their children for lead poisoning. (2024, August 9). WBAY. https://www.wbay.com/2024/08/09/dhs-asking-parents-test-their-children-lead-poisoning/