Epic Research is not viewable using Internet Explorer. Please try accessing it with an alternate browser.
Cosmos Study

Patients with Diabetes, with a Rural Residence, or Who Are Black Experience Higher Risk of Stillbirth

October 16, 2025
Dual-Team Study
Team A:Kersten Bartelt, RNGrant Keane
Team B:Anna Miller, RNEmily Higgs

Key Findings

  • Patients who are Black, patients who live in non-urban areas, and patients with diabetes each have an increased likelihood of stillbirth after 20 weeks gestation.
  • Thrombophilia, severe obesity, hypertension, and chronic kidney disease were associated with higher likelihood of stillbirth at some stages.

Stillbirth (fetal death at 20 or more weeks gestation) is a major cause of perinatal loss, with long-term impacts on families and public health.1 While certain risk factors are well-documented, less is known about whether they are specific to early, late, or term stillbirth. We aimed to further understand timing-specific patterns, highlighting opportunities for targeted prevention.

We studied 246,775 pregnancies that occurred between January 1, 2017, and May 1, 2025, including those that had a miscarriage and those that did not, and matched pregnancies based on maternal age, gravidity, prior neonatal or fetal demise, and whether the pregnancy had more than one fetus. We accounted for demographics, BMI, smoking, rurality, census region, residence in a socially vulnerable area, multiple gestation status, maternal conditions, obstetric history, and prenatal care timing. Stillbirths were classified as early (20 to 27 weeks), late (28 to 36 weeks), or term (≥37 weeks).

Mothers who are Black experience markedly higher likelihood of stillbirths at each stage of stillbirth—up to 87% more likely compared to those who are White—as seen in Figure 1. A 9% increase in early pregnancy stillbirth was observed for Hispanic mothers. For other non-White mothers, representation was too low to establish statistical significance.

Figure 1
Stillbirth Likelihood by Race and Ethnicity
Stillbirth Likelihood by Race and Ethnicity
Figure 1. The likelihood of stillbirth by maternal race and ethnicity.

Mothers living in more rural areas are up to 35% more likely to experience a stillbirth compared to those living in more urban areas, as seen in Figure 2.

Figure 2
Stillbirth Likelihood by Rurality
Stillbirth Likelihood by Rurality
Figure 2. The likelihood of stillbirth by rurality.

We evaluated 20 maternal conditions that could potentially influence the risk of stillbirth. Figure 3 shows those with the strongest correlation. Patients with diabetes consistently had increased likelihood of stillbirth across all stages. Mothers who had thrombophilia, severe obesity, hypertension, or chronic kidney disease (CKD), on the other hand, had varying relationships with the likelihood of stillbirth at different stages. For the results of all studied factors, see the tables in the PDF version of the brief.

Figure 3
Stillbirth Likelihood by Maternal Conditions
Stillbirth Likelihood by Maternal Conditions
Figure 3. The likelihood of stillbirth by maternal conditions.

These data come from Cosmos, a dataset created in collaboration with a community of Epic health systems representing more than 300 million patient records from 1,800 hospitals and more than 41,000 clinics from all 50 U.S. states, Canada, Lebanon, and Saudi Arabia. This study was completed by two teams that worked independently, each composed of a clinician and research scientists. The two teams came to similar conclusions. Graphics by Brian Olson. 

References

  1. American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine. Management of stillbirth: Obstetric care consensus no, 10: Obstetric care consensus no, 10. Obstet Gynecol. 2020;135(3):e110-e132. doi:10.1097/AOG.0000000000003719

Data Definitions

Study period
Study population: inclusion
Study population: exclusion
Confounders
Outpatient face-to-face
Outcomes
Model specifications
Limitations