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Prostate cancer screening rates have increased for men aged 45 and older since 2021, with the most pronounced increase seen in men aged 55–64 rising by nearly 50% from Q1 2021 to Q4 2025.

CHF exacerbations were 40–60% more likely for patients who had their diuretic frequency increased compared to those who had their diuretic dosage increased.

After starting antihypertensive therapy, patients with a high proportion of telehealth encounters (50–74% of outpatient visits) had systolic blood pressure levels comparable to those with entirely in-person care throughout the first 12 weeks.

Male patients aged 10 to 15 who had an ED visit for a motor vehicle crash (MVC) were as much as four times as likely to experience a subsequent firearm injury compared with those whose ED visit was for a fall, in some parts of the United States.

Infants 5 to 8 weeks old with a low body temperature were 42% to 53% more likely to have a bacterial infection compared to infants of the same age with a normal temperature.

Women who were prescribed progestin-only birth control were less likely to be diagnosed with migraines compared to those not using hormonal contraception.

Among patients with type 2 diabetes, GLP-1 use was associated with a 32% lower fracture risk for those with either osteopenia or osteoporosis.

Across all lipid-lowering drug classes, men had a 4.5-percentage point greater reduction in LDL than women.

Primary adherence (prescription filled within 30 days) was lowest for self-pay patients and highest for commercially insured and Medicare Advantage patients for statins, antihypertensives, and diabetes medications.

Among patients with type 1 diabetes, inhaled insulin use was associated with a 0.68 percentage point reduction in average HbA1c, while injectable insulin was associated with a 0.82 percentage point reduction.

Use of suzetrigine, a non-opioid pain medication, has risen steadily each month since its approval in February 2025, with over half of the prescriptions occurring in July and August.

Hormone replacement therapy (HRT) prescriptions increased 72% from Q2 2021 to Q3 2025 among women aged 50 to 65, from 29.3 prescriptions per 1,000 women to 50.4 prescriptions per 1,000 women.

Among patients with polycystic ovary syndrome (PCOS), the median one-year weight change was an 11.5% loss for those treated with a GLP-1, compared to a 1.9% loss among those treated with metformin.

Children born to mothers diagnosed with intrahepatic cholestasis of pregnancy (ICP) were 31% more likely to have a motor delay diagnosed by age 5 compared to those born to mothers without a diagnosis of ICP.

Patients diagnosed with kidney cancer during the pandemic were 25% more likely to die in the three years following their diagnosis compared to those diagnosed before the pandemic.

In October, the weekly rate of medically attended hand, foot, and mouth disease (HFMD) reached more than three times the highest weekly rate in 2024 and nearly twice the highest weekly rate in 2023.

Total firearm injury rates nearly doubled during the COVID-19 pandemic, peaking at 1.8 per 1,000 emergency department (ED) visits in Q2 2020. These rates have since dropped and reached pre-pandemic levels by Q4 2023.

Nebraska and Kansas have the highest rates of Parkinson’s disease among U.S. states studied, with 620 and 596 people diagnosed per 100,000 patients, respectively. Even after adjusting for other factors like age, sex, and comorbidities, Nebraska and Kansas continue to have the highest rates among U.S. states, suggesting the elevation is not solely due to demographics.

Patients who are Black, patients who live in non-urban areas, and patients with diabetes each have an increased likelihood of stillbirth after 20 weeks gestation.

Among non-diabetic patients without chronic kidney disease (CKD), there was a minimal increase of 0.01 mg/dL to 0.02 mg/dL in serum creatinine in the months following initiation of semaglutide, liraglutide, or tirzepatide. Of note, creatinine values can vary up to 0.6 mg/dL and still be considered within the normal range.