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Among non-diabetic patients without chronic kidney disease (CKD), there was a minimal increase of 0.01 mg/dL to 0.02 mg/dL in serum creatinine in the months following initiation of semaglutide, liraglutide, or tirzepatide. Of note, creatinine values can vary up to 0.6 mg/dL and still be considered within the normal range.

The risks of myocardial infarction (MI), ischemic stroke, and hemorrhagic stroke are increased for patients with high or low average systolic blood pressure (BP). The risks are greater at very low systolic BP than at very high systolic BP.

Women with a history of miscarriages who received progesterone in the year before their pregnancy were 18% less likely to experience a miscarriage than those who did not receive progesterone before their pregnancy.

Patients prescribed two concurrent QT-prolonging medications experienced ventricular tachycardia (a type of abnormal heart rhythm) and myocardial infarction at similar rates to patients prescribed only one such medication.

At 24 months post-cessation, 56% of semaglutide, 52% of liraglutide, and 55% of tirzepatide patients kept the weight off or lost additional weight.

Neonatal sepsis diagnosis rates declined steadily from 2015 to 2023. The most pronounced reductions were among Black infants, whose sepsis rate dropped by nearly half, from 2.4% in 2015 to 1.3% in 2023.

The rate of opioid prescriptions at discharge after childbirth declined by 43% between 2017 and 2024, falling from 502 per 1,000 mothers to 285 per 1,000 mothers.

Vaccine effectiveness against RSV infection declined from 71% at 4 months post-vaccination to 40% by 19 months post-vaccination.

Patients on selective serotonin reuptake inhibitor (SSRI) antidepressants for three to eight years showed an 18% lower risk of developing hematologic cancer compared to those not on an SSRI.

The median age at autism diagnosis declined slightly from 7 years of age in 2015 to 6 years in 2024. Male patients are increasingly diagnosed earlier with the median age at diagnosis dropping from 7 years in 2015 to 5 in 2024. However, the median age for females remained near 8 years over the same period.

Nondiabetic adults prescribed a continuous glucose monitor (CGM), intermittent glucose monitoring (such as testing strips), or no glucose monitoring had negligible changes to their average HbA1c 6 to 18 months following their prescription or initial HbA1c.

Diabetic patients with an HbA1c between 7.0 and 7.4% are 13% more likely to experience a novel myocardial infarction (MI) and 8% more likely to experience a novel stroke compared to those with an HbA1c between 6.75 and 6.99%.

Patients who sustained a ≥10% weight loss over 18 months had an average LDL reduction of 6.2 mg/dL, compared to 2.7 mg/dL among patients who had little to no weight change and 1.9 mg/dL among those who lost and then regained weight. 

The rate of endometriosis diagnoses per 10,000 patients increased 32% from 24.9 in 2017 to 32.8 in 2024.

Hospitalization rates in the 30 days following an influenza infection have risen in recent seasons, from 4.9% in 2022/2023, 5.6% in 2023/2024, and 7.0% in 2024/2025. Before the COVID-19 pandemic, rates trended slightly down, reaching 4.2% in the 2019/2020 season.

Children prescribed 5 to 9 courses of antibiotics before age 5 are 7% more likely to be obese at age 6 compared to those with no antibiotic exposure. Those prescribed 10 or more antibiotics before age 5 are 14% more likely to become obese at age 6. 

Nondiabetic patients with higher HbA1c levels are more likely to experience novel myocardial infarction (MI). Those with an average HbA1c of 5.4–5.6% are 6% more likely compared to those with an HbA1c between 5.0 and 5.3%. The increase is greater with higher average HbA1c levels, reaching 21% more likely among those with an HbA1c of 6.1–6.4%. 

In support of the widely held understanding that first babies are more likely to be born “late,” we found that deliveries go beyond 41 weeks’ gestation 1.53 times more frequently among mothers with a first-time delivery compared to those who have previously delivered, confirming anecdotal wisdom.

Patients with an active patient portal account at the time of scheduling their appointment were 21.5 % less likely to no-show than those without an account, with a no-show rate of 6.2% for those with a patient portal account compared to 7.9% for those without. 

Patients with bone density disorders prescribed bisphosphonates are 5% less likely to experience an ischemic stroke than those prescribed calcium or vitamin D.