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It is largely unknown how COVID-19 in pregnancy affects a newborn. To date, studies have shown varied findings and most have had small sample sizes. We studied a large population of 151,548 pregnant mothers, of whom 4,054 were COVID-19-positive at some point during their pregnancy.

Newly available data shows that the rise in the number of new COVID-19 cases in the fall of 2020 was accompanied by a decline in non-COVID-19 hospital admissions during that time period. Our analysis includes medical records data of hospital admissions through December 5, 2020 from the Epic Health Research Network and updates an earlier paper that analyzed hospital admissions data through August 8, 2020. These new data provide additional information to help assess the economic impact of the COVID-19 pandemic on hospitals and insurers and also adds to our understanding of the extent to which people are continuing to delay or forgo care nearly one year into the pandemic.

Research by the CDC’s National Syndromic Surveillance Program and Jeffery et al showed a substantial drop in ED visit volume at the onset of the COVID-19 pandemic. Anecdotal evidence suggested that patients with urgent conditions were not seeking care for fear of COVID-19 exposure or wanting to limit burden on the healthcare system. In our data, weekly ED visits dropped as low as 50% of predicted visit volume and have since only recovered to approximately 75% of predicted volume. While visit volume declined, the character of the remaining ED visits also changed. The patients who did present to the ED tended to have higher acuity problems (e.g., more likely to result in serious harm or death without attention). The average presentation of all types of problems was also more severe resulting in higher hospital admission rates. We theorize this shift is because patients with less severe presentations, regardless of acuity, appeared less likely to present to the ED during the pandemic.

Our data show an increased risk of hospitalization with oxygen support for pregnant women with COVID-19. While there is no evidence of increased risk during the first trimester of pregnancy, pregnant women in their second and third trimesters face an elevated risk of hospitalization requiring oxygen support and, often, an elevated risk of ventilation or ICU care.

By early December 2020, over 100,000 patients are hospitalized with COVID-19 in the United States. Two key variables in understanding the stress to the health system due to new COVID-19 hospitalizations are the availability of staff and ICU beds. We analyzed these for 809 hospitals in metro, suburban, and rural settings from July 2020 to December 3, 2020.

Our results show that the LUMC screening tool performed significantly better than qSOFA when challenged with real patient data in identifying CMS SEP-1 patients. As early detection is paramount in the management of sepsis and in order to ensure that sepsis is being properly treated and documented in compliance with the CMS SEP-1 core measure, it is important to use the same definitions as the CMS SEP-1 and thus attempt to have a screening tool that is more accurate for this measure…

Patients hospitalized with COVID-19 are more likely to develop sepsis and septic shock when compared to patients admitted with influenza during the 2016, 2017, or 2018 flu seasons, according to EHR data. To explore the incidence of sepsis in COVID-19 compared to other viral illnesses, we examined data from patients who were admitted to the hospital during their COVID-19 illness (n=66,236)…

In the first seven months of the novel coronavirus pandemic, inpatient therapy choices have been considerably influenced by pre-publications, media attention, clinical trials, emergency use authorizations, and regional drug availability. In this observational study, we examine patterns in inpatient medication use since the start of the pandemic. Use of the leading therapies over time represents the dramatic changes in standard of care for treating hospitalized patients with COVID-19. Dexamethasone and remdesivir are the current dominant therapeutics, and both of these therapies have supportive evidence from randomized clinical trials…

Hospital admissions declined by nearly a third this spring as concern about the coronavirus pandemic took hold and hospitals limited non-urgent procedures and Americans cut back on non-urgent care, but had rebounded to near-normal levels by mid-summer, according to a new analysis by Epic Health Research Network and KFF…

Provider organizations increasingly allow incorporation of patient-generated data into electronic health records (EHRs). In 2015, we began allowing patients to upload data to our EHR without physician orders, which we henceforth call patient-initiated data (PAIDA). Syncing wearable heart rate monitors to our EHR allows for uploading of thousands of heart rates per patient per week.

Asthma appears to have a more significant impact on outcomes in younger COVID-19 patients. We suggest that the additional risk associated with asthma is overshadowed in older patients by their already elevated risk…

• Racial disparities in hospitalization and death persisted among positive patients even after controlling for certain sociodemographic factors and underlying differences in health, with Asian patients exhibiting the highest relative risk.
• Differences in testing rates by race and ethnicity were small, but people of color were more likely, compared to White patients, to be positive when tested and to require a higher level of care at the time they tested positive for COVID-19.

Interest in the demographic characteristics of people with COVID-19 has been high since the start of the pandemic. Initially, when testing resources were scarce and often limited to the sickest patients, older adults represented a higher proportion of patients than young people. Beginning in June, demographics shifted and young people now represent the largest subgroup of COVID-19 cases…

The first collaborative study with the COVID-19 Healthcare Coalition looked at the impact of famotidine treatment on the risk of death in admitted COVID-19 positive patients. Each data partner performed an identical independent analysis on their own aggregated dataset. The final conclusion from each data source was the same: rapid famotidine treatment does not reduce the risk of death among admitted COVID-19 patients, even when adjusting for age, sex, and comorbidities…

The CDC has raised concerns about increased isolation, fear, and anxiety during the pandemic. This brief examines how COVID-19 changed care delivery patterns for patients with anxiety or depression, in both established and newly diagnosed patients. Additionally, our analysis shows the initial steep drop-off in total visits has returned to pre-pandemic levels, with telehealth compensating for the reduction in office visits…

Earlier this year, we published data demonstrating a 300-fold increase in telehealth, broken down by encounter reason and specialty. Many speculated that telehealth volumes would remain high throughout (and perhaps beyond) the pandemic; however, recent EHR data show that volumes peaked in mid-April. Since then, levels have dropped to make up only 21% of total visits, though this is still much higher than the rates seen before the pandemic…

Public policy decisions in the United States have relied on epidemiologic models that predict the course of the COVID-19 pandemic. We compared the assumptions in the IHME model to a sample of admissions across 21 states, and found the median estimates differ from the assumptions…

Our analysis found a dramatic–but temporary–decrease in procedures for cardiac arrhythmia and coronary artery disease, as well as procedures for all of the major organ cancers we examined. At their lowest point, these procedure volumes were 49-88% below their historical weekly averages…

Patients with severely elevated liver enzymes during admission for COVID-19 showed 2.5 times higher mortality rates when compared to patients with normal or moderately elevated levels…

Early in the COVID-19 pandemic, experts expressed concerns that hypertensive patients taking RAAS inhibitors to control blood pressure might be at a higher risk of increased COVID-19 disease severity and mortality. However, analysis of EHR data suggests…